Adaptation and Validation of the Constructivist Teaching Practices Inventory in Elementary Physical Education (CTPI-EPE) for Brazilian Physical Education Pre-Service Teachers.

Constructivism is used as a powerful theoretical outlook to support teaching, learning, and curriculum in physical education and sport. The Constructivist Teaching Practices Inventory in Elementary Physical Education (CTPI-EPE) is a valid instrument for assessing in-service teachers. However, there is a need to translate constructivist teaching practices for PE into other languages. This study examined the validity of the Portuguese version of the adapted CTPI-EPE for Brazilian physical education preservice teachers (PST). The sample comprised of 869 physical education PSTs from Brazil. Data were collected through an online form. Aiken's V was used to examine content validity, and Bayesian methods used for exploratory and confirmatory factor analysis. The results showed adequate content and internal structure of the translated and adapted questionnaire. This study highlighted the validity of the Portuguese version of the CTPI-EPE, which could be considered an important instrument for self-reflection by PSTs, and provide information for improved training in higher education toward constructivist teaching.

Deliberate Practice, Functional Performance and Psychological Characteristics in Young Basketball Players: A Bayesian Multilevel Analysis.

BACKGROUND: Early sport specialization has increased its popularity mostly based on the deliberate practice theory premises. In this study, we examined the influence of the age of onset of deliberate basketball practice on body size, functional performance (countermovement jump, line drill and yo-yo intermittent recovery level 1), motivation for achievement and competitiveness, motivation for deliberate practice and sources of enjoyment among young Brazilian basketball players. In addition, we adjusted for the influence of gender, age group, maturity status and state basketball federation on the outcomes. METHODS: The sample included 120 female and 201 male adolescent basketball players aged 14.0 (1.7) years, on average. We grouped players by the age of onset of deliberate basketball practice as related to biologic maturation milestones (pre-puberty deliberate practice onset, mid-puberty deliberate practice onset and late-puberty deliberate practice onset). RESULTS: There was no substantial variation among contrasting players by the onset of deliberate practice in all of the outcomes. Adjusting for gender, male players with late-puberty deliberate practice onset had better functional performance than players with pre- and mid-puberty onset of practice. Females players with late-puberty deliberate practice onset had slightly worst functional performance than players with pre- and mid-puberty onset of practice. CONCLUSIONS: Early deliberate basketball practice does not appear to provide an advantage for the development of physiological functions. Likewise, enjoyment, motivation for deliberate practice and motivation for achievement and competition do not appear to be negatively influenced by early deliberate basketball practice. The debate about the relationship between time spent in deliberate practice and performance development in young athletes will need to emphasize the coaching pedagogical quality and the training environment and account for informal practice and deliberate play.

Análisis de Cienciometría y Patentometría para Determinar el Panorama de Conocimiento en Tecnologías de Innovación: Dos Equipos de Ultrasonido Terapéuticos / Scientometric and Patentometric Analysis to Determine the Knowledge Landscape in Innovation Technologies: The Therapeutic Ultrasound Equipments

Resumen En este artículo se propone un modelo de información para determinar el panorama de las tecnologías emergentes relacionadas con los equipos de terapia de ultrasonido, el cual permite la identificación de cuatro grandes categorías en el área de la investigación y el desarrollo dentro del campo, utilizando una metodología competitiva que incorpora la evaluación de publicaciones científicas y un análisis de patentes; utilizando distintas bases de datos mediante la agrupación por palabras clave y cronología. Se examinaron las bases de datos de Google Académico, Scopus, Springer, Sage Journals, ScienceDirect y Academic.edu para consultar artículos y publicaciones científicas; se encontraron alrededor de 67,000 artículos de los cuales únicamente 119 cumplen con los criterios de exclusión, en donde se analizó cómo está conformado un equipo de ultrasonido, sus distintas aplicaciones y nuevas tendencias desde un enfoque de interfaz humano computadora. Las bases de datos utilizadas para la recolección de las patentes fueron Patentscope, Google Patents, e Invenes, así como las bases de WIPO y USPTO; en las cuales se encontraron alrededor 421 patentes con relación a los equipos de ultrasonido, los países en los que se registró la patente y la forma en la que la clasifican. Finalmente, sólo 16 patentes cumplen con los criterios de exclusión. Los resultados indican que Estados Unidos es la nación con más difusión tanto en la publicación de artículos como en patentes.

Abstract This paper proposes an information model to determine the panorama of emerging technologies related to ultrasound equipment, which allows the identification of four main categories of research and development within the field, using a competitive methodology that incorporates the evaluation of scientific publications and a patent analysis; by using different databases by keywords clustering and years relevance. Google Scholar, Scopus, Springer, Sage Journals, ScienceDirect and Academic.edu databases were examined to consult articles and scientific publications; about 67,000 articles were found, of which only 119 met the exclusion criteria, the different parts of an ultrasound equipment, its different applications and new trends were analysed. The databases of Patentscope, Google Patents, and Invenes, as well as the bases of WIPO and USPTO were used for the recollection of patents; in which about 421 patents were found in relation to ultrasound equipment, the country in which the patent was registered and the way it is classified. Finally, only 16 patents meet the exclusion criteria. The results show USA as the country with the most diffusion rate in publishing articles and patents.

Performance, motivation, and enjoyment in young female basketball players: An interdisciplinary approach.

The purpose of this study was to examine the variation in accumulated basketball training experience, body size, functional performance, deliberate practice motivation, achievement and competitiveness motivation and sources of enjoyment among young female basketball players, partitioning the potential variation by individuals´ biological characteristics (menarche status) and contextual characteristics (competitive age group and competitive level). We considered 114 adolescent female basketball players aged 14.3 (1.8) years. We used multilevel regression and poststratification estimations. The adolescent female basketball players selected for state-level had more accumulated experience, were taller and with better functional performance. Conditional on the data, youth female coaches tend to value (probably overvalue) size and function when selecting/promoting players, even at early age groups, likely contributing to an overrepresentation of early maturing girls in at early age groups. Players from club- and state-level were similarly highly motivated for deliberate practice and to achievement. Only for competitiveness, state-level players had higher values than club level players. The sources of enjoyment were influenced by context (competitive levels) for self-referenced competencies and others-referenced competencies. Structured programs of training and competition in youth female basketball provide a nurturing environment for the development of players´ engagement and commitment to training and excellence attainment.

Determinants of drop-out in youth basketball: an interdisciplinary approach.

Using an interdisciplinary approach, we examined the baseline variation in biological maturity status, training experience, body size, functional capacities (Line Drill test and Yo-Yo Intermittent Recovery level 1 test) and motivation for achievement, competitiveness and deliberate practice of youth basketball players according to their participation status in the sport two years after assessment. Fifty-seven players were considered (10.5 to 15.5 years). Two years later we ascertained whether players discontinued participation (dropout), or remained playing engaged within a structured basketball training program. Taller adolescent players were more likely to be selected/promoted in youth basketball regardless of their lower functional capacity. Achievement and competitiveness motivation (will to excel and competitiveness) were related to dropping out or persisting in this sample of youth basketball players. Overall, there is a need to consider the interaction between physical growth, biological maturation, functional capacities and behavioural characteristics, specifically among players on the path to sport expertise.

Interactions of tetracyclines with milk allergenic protein (casein): a molecular and biological approach.

Tetracycline (TC), oxytetracycline (OTC), and chlortetracycline (CTC) interactions with the allergenic milk protein casein (CAS) were here evaluated simulating food conditions. The antibiotics assessed interact with CAS through static quenching and form non-fluorescent complexes. At 30 °C, the binding constant (Kb) varied from 0.05 to 1.23 × 106 M-1. Tetracycline interacts with CAS preferably through electrostatic forces, while oxytetracycline and chlortetracycline interactions occur by hydrogen bonds and van der Waals forces. The interaction process is spontaneous, and the magnitude of interaction based on Kb values, followed the order: TC < CTC < OTC. The distances between the donor (protein) and the receptors (TC, OTC, and CTC) were determined by Förster resonance energy transfer (FRET) and varied from 3.67 to 4.08 nm. Under natural feeding conditions, the citrate decreased the affinity between TC and CAS; a similar effect was observed for OTC in the presence of Ca(II), Fe(III) and lactose. Synchronized and three-dimensional (3D) fluorescence studies indicated alterations in the original protein conformation due to the interaction process, which may influence allergenic processes. In addition, complexation with CAS modulated the antimicrobial activity of CTC against S. aureus, demonstrated that the interaction process possibly alters the biological properties of antibiotics and the own protein, in the food conditions.Communicated by Ramaswamy H. Sarma.

Coach Turnover in Top Professional Brazilian Football Championship: A Multilevel Survival Analysis.

In this study, we examined the probability of coaches' survival in the top Brazilian professional football championship considering variation across the competitive seasons between 2012 and 2017, considering a multilevel framework. We also considered whether previous coaching experience in the top Brazilian professional football championship would change the probability of coaches' survival across the season. The data considered 4,560 games from the top professional Brazilian football league (Campeonato Brasileiro Série A) between the 2012 and 2017 seasons. At the start of each season, the coach from each team was followed, being recorded at the time the event occurred, i.e., the coach being sacked. A total survival of 120 coaches was considered between the seasons of 2012 and 2017, i.e., 20 coaches at the beginning of each season. Coaches were assigned as novice (no previous experience as head coach in the top Brazilian championship) or experienced (with at least some previous experience as head coach in the top Brazilian championship). Data were available and extracted from the official website of the Brazilian Football Confederation. On average and considering un-pooled observations, the median life of a coach was about 16.5 rounds. Considering variation between 2012 and 2017 seasons, only about 26.3% (95% CI: 18.2-36.1) of the coaches ended a season without being sacked. By mid-season, at round 19, the probability of coaches' survival was 0.42 (95% CI: 0.32-0.53). Variation between season on survival estimates per round was substantial (between-season standard deviation = 0.48, 95% credible intervals: 0.25-0.95; corresponding to an inverse logit = 0.62, 95% CI: 0.56-0.72). There was no substantial variation between novice and experienced coaches' survival probability. The present results expose the vulnerability of the coaching context in Brazilian football, potentially highlighting an excessive emphasis on short-term results to mediate club management decisions.

[Primary central nervous system lymphoma: clinical experience in a neurological center]. / Linfoma primario del sistema nervioso central: experiencia clinica en un centro neurologico.

INTRODUCTION: Primary lymphoma of the central nervous system is a variety of non-Hodgkin's lymphoma that accounts for 4-5% of intracranial tumours and 5% of all lymphomas. It has its origin in the brain, the eyes, the leptomeninges and the spinal cord with no systemic evidence of lymphomatoid activity; the subtype of lymphoma is predominantly of B-type cells. PATIENTS AND METHODS: We conducted a descriptive study of the patients diagnosed with primary brain lymphoma who were attended to at third-level centres in Mexico between the years 1980 and 2016. Patients who had been screened for systemic lymphoma were included. The results were analysed by means of simple frequencies, and disease-free and overall survival time was analysed by Kaplan-Meier curves; the differences among curves were analysed by means of log rank. RESULTS: Of a total of 215 patients, there were only 74 cases. By sex, 45% were females and 55% were males. Regarding age, 36.7% were over 60 years old. The most frequent clinical manifestations were motor loss (60%) and cognitive disorders (52%). Most patients received some form of chemotherapy (89%). The only significant factor for radiological response and clinical prognosis was the combined use of radiochemotherapy (p = 0.04493). CONCLUSION: Lymphoma is a tumorous condition with a high clinicoradiological response to treatment, although the response is not long-lasting. Its early identification and multidisciplinary management are essential for a more favourable prognosis in these patients.

TITLE: Linfoma primario del sistema nervioso central: experiencia clinica en un centro neurologico.Introduccion. El linfoma primario del sistema nervioso central es una variedad de linfoma no Hodgkin que representa el 4-5% de los tumores intracraneales y el 5% de todos los linfomas. Se origina en el encefalo, los ojos, la leptomeninge y la medula espinal sin evidencia sistemica de actividad linfomatoide; el subtipo de linfoma mayoritariamente es de celulas de tipo B. Pacientes y metodos. Estudio descriptivo de los pacientes diagnosticados con linfoma cerebral primario que fueron atendidos en centros de tercer nivel en Mexico entre los años 1980 y 2016. Se incluyo a los pacientes que contaran con cribado para busqueda de linfoma sistemico. Los resultados se analizaron mediante frecuencias simples; en el caso del tiempo libre de enfermedad y supervivencia global, mediante curvas de Kaplan-Meier, y las diferencias entre curvas, mediante log rank. Resultados. En un total de 215 pacientes solo hubo 74 casos. El 45% fueron mujeres y el 55%, hombres. El 36,7% eran mayores de 60 años. Las manifestaciones clinicas mas frecuentes fueron deficit motor (60%) y alteraciones cognitivas (52%). La mayoria recibio alguna forma de quimioterapia (89%). El unico factor significativo para respuesta radiologica y pronostico clinico era el uso combinado de radioquimioterapia (p = 0,04493). Conclusion. El linfoma representa una patologia tumoral con alta respuesta clinicorradiologica al tratamiento, aunque la respuesta no es duradera. Es fundamental su identificacion temprana y el tratamiento multidisciplinario para el mejor pronostico de estos pacientes.

Influence of age and maturation on perceived collective efficacy in youth basketball players / Influencia de la edad y la maduración en la eficacia colectiva percibida en jóvenes jugadores de baloncesto / Influência da idade e da maturação na eficácia coletiva percebida em jovens jogadores de basquetebol

Growth and maturation impact the development of young athletes' physique and function. It is likely that psychological and behavioral characteristics will also be impacted by maturity status. Perceived collective efficacy (CE) is a potential mediator of sports performance and may be influenciated by maturity status. Therefore, this study examined the perceived CE variation between young basketball players accounting for the influence of chronological age and biological maturity status. The sample included 57 adolescent basketball players aged 9.5 to 15.5 years. Chronological age, estimated age at peak height velocity (PHV) and CE through the Portuguese version of the Collective Efficacy Questionnaire for Sports were considered. Bayesian multilevel modeling was used to examine athletes' perceived CE dimensions variation by maturity status and age. Overall, the adolescent basketball players' perceived CE scores were high for all dimensions: ability (8.77±1.15); effort (9.20±1.03); persistence (8.87±1.18); preparation (8.96±1.08); unity (8.88±1.22). The variability estimates were very large, suggesting that the influence of maturity status on variation may be residual. There was no substantial relation between chronological age and the variation scores, although the results suggest that perceived variation was independent of chronological age variation and between players variation in maturity status. Further study examining the relations of growth, functional performance development, and perceived CE would be relevant for the holistic understanding of young basketball players' development

El crecimiento y la maduración afectan el desarrollo físico y la función de jóvenes atletas, y también pueden influir en sus características psicológicas y comportamentales. La eficaciacolectiva (EC), una medida psicológica y un mediador potencial del rendimiento deportivo, puede verse influida por la etapa maduracional. Sin embargo, hay poca información disponible sobre las percepciones de jóvenes jugadores sobre la EC y la relación entre la CE y la etapa maduracional de jóvenes atletas. Así, este estudio examinó la variación de la EC entre jóvenes jugadores de baloncesto, considerando la influencia de la edad cronológica y de la etapa maduracional. Fueron considerados y analizados, en su edad cronológica, la edad estimada en el pico de velocidad de crecimiento (PHV) y la EC, 57 jugadores de baloncesto de 9,5 a 15,5 años a través de la versión Inglesa del Cuestionario de Eficacia Colectiva para Deportes. Una serie de modelos Bayesianos de regresión lineal multinivel fue utilizada para estimar la EC percibida por los atletas de acuerdo con sus edadescronológicasy etapas maduracionales. En general, los escores de EC de los atletas fueron elevados en todas las dimensiones: habilidad (8,77±1,15); esfuerzo (9,20±1,03); persistencia (8,87±1,18); preparación (8,96±1,08);unidad (8,88±1,22). Las estimaciones de variabilidad fueron muy grandes, sugiriendo que la influencia de la etapa maduracional sobre la EC es residual. No hubo relación sustancial entre la edad cronológica y los escores de EC, aunque los resultados sugieren que la EC fue independiente de la variación de la edad cronológica y de la variación en las etapas maduracionales entre los atletas. Dada la pequeña y localizada muestra investigada, se sugieren estudios adicionales que examinen las relaciones entre edad cronológica, etapa maduracional y EC para comprender mejor el desarrollo de los atletas jóvenes en el deporte

O crescimento e a maturação afetam o desenvolvimento físico e a função de atletas jovens, e também podem influenciar suas características psicológicas e comportamentais. A eficácia coletiva (EC), uma medida psicológica e potencial mediadora do desempenho esportivo, pode ser influenciada pelo estágio maturacional. No entanto, há escassa informação disponível sobre a percepção de EC de jovens jogadoresesobre e a relação entre a EC e o estágio maturacional. Portanto, este estudo examinou a variação da EC entre jovens jogadores de basquetebol, considerando a influência da idade cronológica e do estágio maturacional. Foram considerados e analisados em sua idade cronológica, na idade estimada no pico de velocidade de crescimento (PHV) e na EC, 57 atletas de basquetebol adolescentes com idades entre 9,5 e 15,5 anos por meio da versão portuguesa do Questionário de Eficácia Coletiva para Esportes. Utilizou-se uma série de modelos Bayesianos de regressão linear multinível para estimar a EC percebida pelos atletas de acordo com sua idade cronológica e estágios maturacionais. No geral, os escores de EC dos atletas foram elevados em todas as dimensões: capacidade (8,77±1,15); esforço (9,20±1,03); persistência (8,87±1,18); preparação (8,96±1,08); unidade (8,88±1,22). As estimativas de variabilidade foram muito grandes, sugerindo que a influência do estágio maturacional sobre a EC seja residual. Não houve relação substancial entre a idade cronológica e os escores de EC, embora os resultados sugiram que a EC percebida tenha sido independente da variação da idade cronológica e da variação nos estágios maturacionais entre os atletas. Considerando a amostra pequena e localizada investigada, sugerem-se estudos adicionais que examinem as relações entre idade cronológica, estágio maturacional e EC para melhor entender o desenvolvimento dos jovens atletas no esporte

Variation in perceived collective efficacy among adolescent basketball players across 4-month competitive season / Variación en la eficacia colectiva percibida entre jugadores de baloncesto adolescentes a lo largo de una temporada competitiva de 4 meses / Variação na eficácia coletiva percebida entre jogadores adolescentes de basquetebol ao longo de uma temporada competitiva de 4 meses

In sports, collective efficacy appears to be dependent on the interactions and organized dynamics between the players within the team. It is directly related to team ́s performance potential. This study examined the changes of perceived collective efficacy among young basketball players between 10 to 17 years across a 4-month competitive season, accounting for variation by age group. We explored the trends of perceived collective efficacy based on repeated measures across 4 months within the observed age range. Sixty-five adolescent male basketball players aged 13,7 (9,5 to 17,3) years at baseline were considered. Collective Efficacy Questionnaire for Sports (CEQS) was used to assess players ́ perception of collective efficacy. Players had high CEQS scores. Except for persistence, all CEQS factors did not vary by age group. No distinct trend of differences between age group was present. CEQS factors remained high on the second assessment, except for abilitywhere there was a systematic decrease of the scores at end-season. A negative trend was apparent forpersistence, preparationand unityas players were closer to late adolescence years. Overall, adolescent basketball players tend to have a positive perception of theirs and their teammates efficacy. Despite the small to trivial influence of exposure to training and competition during pubertal years observed, results suggest that approaching adult level may change negatively the efficacy perceptions of adolescent players. Hence, coaches and practitioners of youth basketball should consider that players ́ collective efficacy perceptions may vary as transient influences of pubertal growth and competitive level with age increase

La eficacia colectiva en los deportes parece depender de las interacciones y dinámicas organizadas entre los jugadores del equipo. Está directamente relacionada con su potencial de rendimiento. Examinamos los cambios de eficacia colectiva percibidos entre jóvenes jugadores de baloncesto (10 a 17 años) por 4 meses de temporada competitiva, controlando la variación por grupo de edad. Exploramos las tendencias de eficacia colectiva percibida basados por medidas repetidas antes y después de 4 meses. Sesenta y cinco adolescentes jugadores de baloncesto, con 13,7 (9,5 a 17,3) años al inicio del estudio, fueron considerados. Se utilizó el Collective Efficacy Questionnaire for Sports(CEQS) para evaluar la percepción sobre la eficacia colectiva. Los jugadores tuvieron altas puntuaciones en el CEQS. Excepto por la persistencia, los factores del CEQS no variaron por grupo de edad. No hubo diferencias entre los grupos. Los factores del CEQS permanecieron altos en la segunda evaluación, excepto por la habilidaden que hubo una caída en los escores al final de la temporada. Una tendencia negativa fue aparente para la persistencia, preparacióny uniónen los años finales de la adolescencia. En general, los jugadores tienden a tener una percepción positiva de su eficacia y de sus colegas. A pesar de la influencia de la exposición al entrenamiento y la competiciónser pequeña y no significativa durante la edad observada, los resultados sugieren que la aproximación del nivel adulto puede alterar negativamente las percepciones de eficacia de los jugadores. Se debe considerar que las percepciones de eficacia colectivade los jugadores pueden variar como influencias transitorias del crecimiento pubertario y del nivel competitivo con el aumento de la edad

A eficácia coletiva nos esportes parece depender das interações e dinâmicas organizadas entre os jogadores da equipe. Está diretamente relacionada ao seu potencial de desempenho. Examinamos as mudanças de eficácia coletiva percebida entre jovens jogadores de basquetebol (10 a 17 anos) ao longo de 4 meses de temporada competitiva, controlando a variação por faixa etária. Exploramos as tendências de eficácia coletiva percebida com base em medidas repetidas antes e depois de 4 meses. Sessenta e cinco adolescentes jogadores de basquetebol, com 13,7 (9,5 a 17,3) anos no início do estudo, foram considerados. O Collective Efficacy Questionnaire for Sports (CEQS) foi utilizado para avaliar a percepção sobre a eficácia coletiva. Os jogadores tiveram altas pontuações no CEQS. Exceto pela persistência, os fatores do CEQS não variaram por faixa etária. Não houveram diferenças entre as faixas etárias. Os fatores do CEQS permaneceram altos na segunda avaliação, exceto pela habilidadeem que houve uma queda nos escores no final da temporada. Uma tendência negativa foi aparente para a persistência, preparaçãoe uniãonos anos finais da adolescência. Em geral, os jogadores tenderam ter uma percepção positiva de sua eficácia e de seus colegas. Apesar da influência da exposição ao treinamento e competição ser pequena e não significativa durante a idade observada, os resultados sugerem que a aproximação do nível adulto pode alterar negativamente as percepções de eficácia dos jogadores. Devem-se considerar que as percepções de eficácia coletiva dos jogadores podem variar como influências transitórias do crescimento pubertário e do nível competitivo com o aumento da idade

Power and agility testing within the NBA pre-draft combine / Teste de potência e agilidade no NBA pre-draft combine

Abstract Considering agility is a prerequisite for basketball performance and several agility tests have been used during the pre-draft assessment of the National Basketball Association (NBA), the aimed of this study was to examine the associations between pre-draft athletes´ performance scores in NBA draft combine testing protocol. The performance of 480 athletes invited to the NBA pre-draft assessment from 2010 to 2017 was considered. Tests in the NBA Draft Combine considered in this study included the Shuttle Run Test, Lane Agility Test, Sprint Test, and Jump Test (standing vertical leap). Zero order correlations were calculated to examine the associations between performance tests by fitting Bayesian linear regression models. Among running testing, both Shuttle Run Test [r=0.45, 95% confidence interval (CI) 0.34 to 0.56) and Sprint Test (r=0.45, 95% CI 0.37 to 0.54) were moderately associated with the Lane Agility Test. The association between the Sprint Test and Shuttle Run Test was moderate at best (r=0.27, 95% CI 0.16 to 0.38). Correlations between Jump Test and running tests were moderate to large, ranging from -0.51 to -0.19 (Lane Agility Test: r=-0.33, 95% CI -0.42 to -0.24; Shuttle Run Test: r=-0.19, 95% CI -0.31 to -0.07; Sprint Test: r=-0.51, 95% CI -0.59 to -0.43). As a conclusion, we found a moderate to large correlations between the tests performance of the NBA Draft Combine, implying that the overall procedures may provide in part overlapping information about basketball maximal short term performance.

Resumo O objetivo deste estudo foi examinar as associações entre os escores de desempenho dos atletas no Pre-Draft Combine da NBA. Foram examinados os desempenhos de 480 atletas nas avaliações do Pre-draft Combine da NBA de 2010 a 2017. Os testes do Draft Combine considerados incluíram o Shuttle Run Test, o Lane Agility Test, o Sprint Test e o Jump Test (salto vertical em pé). Correlações de ordem zero foram calculadas para examinar as associações entre os testes de desempenho através da adequação de modelos de regressão linear Bayesiana. Entre os testes de corrida, tanto o teste Shuttle Run (r = 0,45, intervalo de confiança (IC) de 95% 0,34 a 0,56) e teste de Sprint (r = 0,45, IC 95% 0,37 a 0,54) foram moderadamente associados com o Teste Lane Agility. A associação entre o Sprint Test e o Shuttle Run Test foi de moderada para alta (r = 0,27, IC 95% 0,16 a 0,38). As correlações entre o Teste de Salto e os testes de corrida foram de moderada a grande, variando de -0,51 a -0,19 (Lane Agility Test: r = -0,33, IC 95% -0,42 a -0,24; Teste Shuttle Run: r = -0,19, IC 95% -0,31 a -0,07; Teste de Sprint: r = -0,51, IC 95% -0,59 a -0,43). Assim, foi verificado uma correlação de moderada a grande entre o desempenho dos testes do Draft Combine da NBA, o que indica que os procedimentos gerais podem fornecer, parcialmente, informações sobrepostas sobre o desempenho máximo de curto prazo do basquetebol.

Patrones de tratamiento con agentes biológicos, eficacia y sobrevida a largo plazo en pacientes con espondiloartritis axial: Impacto de los factores sociodemográficos en Latinoamérica / Patterns of treatment with biological agents, efficacy and long-term survival in patients with axial spondyloarthritis: Impact of sociodemographic factors in Latin America

Objetivos: Evaluar y comparar la eficacia y la sobrevida a largo plazo de las Drogas Modificadoras de la Enfermedad-biológicas (DME-b) en Espondiloartritis Axial (EsPax) mediante el índice LUNDEX y determinar las variables asociadas a la discontinuación de las mismas. Material y métodos: Estudio multicéntrico de corte transversal. Se incluyeron pacientes con EsPax en tratamiento con DME-b. Se registraron variables sociodemográficas, terapéuticas y clínicas. Se consignaron fechas de inicio del tratamiento con DME-b, tratamiento concomitante, suspensión o cambio de tratamiento, y causas de suspensión. La eficacia terapéutica se definió según BASDAI a los 6, 12 meses y luego anualmente a partir del inicio de la DME-b. Se calculó el índice LUNDEX en estos períodos. Análisis estadístico: Estadística descriptiva. Test de Student y test Chi² o test exacto de Fisher. Curvas de Kaplan-Meier y Log-Rank. Análisis de regresión proporcional de Cox. Resultados: Se estudiaron 101 pacientes con EsPax, 80,2% varones, con una edad mediana de 42 años (RIC 35-54,5) y un tiempo mediano de evolución de la enfermedad de 19,3 años (RIC 9,4-28,8). El 26,7% de los pacientes no tenían seguro de salud. Los agentes anti-TNFα utilizados como 1º DME-b en orden de frecuencia fueron: Etanercept (ETN) 44,6%, Adalimumab (ADA) 41,6%, Infliximab 7,9% y Certolizumab 5,9%. En el 32,7% de los casos, la DME-b se administró en combinación con una droga modificadora de enfermedad convencional. La sobrevida media fue de 66,2 meses (IC 95%: 51,8-80,5). Debido a que ETN y ADA se utilizaron en el 85% de los pacientes estudiados, se realizaron comparaciones solamente entre estos agentes. El tiempo medio de supervivencia acumulada fue significaticamente menor para ETN versus ADA (X 53,18±8,8 vs X 74,8±8,9, Log-Rank p=0,02), siendo la causa principal de suspensión, la falta de provisión de la medicación. El tiempo promedio de supervivencia para aquellos que no tenían seguro de salud fue significativamente menor X 31,9 meses (IC 95%: 19-45) con respecto a aquellos pacientes con dicho seguro X 72,3 meses (IC 95%: 55,3-89,3), p=0,03. Luego de ajustar por factores confundidores, la falta de un seguro de salud fue la única variable asociada en forma independiente con menor supervivencia del DME-b (HR 2,54, IC 95%: 1,18-5,75). El LUNDEX global fue del 52,7% a los 6 meses y del 46,9% a los 12 meses. Conclusiones: La sobrevida promedio del 1º DME-b fue de 5,5 años. La falta de cobertura de salud fue la única variable que influyó negativamente en la sobrevida del tratamiento con el 1º DME-b en pacientes con EsPax.

Objectives: To evaluate and compare the efficacy and long-term survival of biological disease-modifying drugs (b-DMARDs) in Axial Spondyloarthritis (axSpA) using the LUNDEX index and to determine the variables associated with the discontinuation of these drugs. Material and methods: Cross-sectional multicenter study. Patients with axSpA in treatment with b-DMARDs were included. Sociodemographic, therapeutic and clinical variables were recorded. The dates of initiation of treatment with b-DMARDs, concomitant treatment, suspension or change of treatment, and causes of suspension were recorded. Therapeutic efficacy was defined according to BASDAI at 6, 12 months and then annually from the initiation of b-DMARDs. The LUNDEX index was calculated in these periods. Statistical analysis: Descriptive statistics. Student's test and Chi² test or Fisher's exact test. Curves of Kaplan-Meier and Log-Rank. Proportional regression analysis of Cox. Results: 101 patients with axSpA were studied, 80.2% men, with a median age of 42 years (IQR 35-54.5) and a median disease duration of 19.3 years (IQR 9.4-28.8). 26.7% of patients didn´t have health insurance. The frequency of the anti-TNFα agent used as 1st b-DMARD was: Etanercept (ETA) 44.6%, Adalimumab (ADA) 41.6%, Infliximab 7.9%, and Certolizumab 5.9%. In 32.7% of the cases, the b-DMARD was administered in combination with a c-DMARD (conventional disease-modifying drug). The mean survival was 66.2 months (95% CI: 51.8-80.5). As ETA and ADA were used in 85% of the patients, comparisons were made only between these two agents. The mean survival time was significantly lower for ETA vs ADA (X 53.18 ±8.8 vs X 74.8±8.9, Log-Rank p=0.02), being the main cause of suspension, the lack of drug provision. The average survival time for those who didn´t have health insurance was significantly lower X 31.9 months (95% CI: 19-45) in comparison to those patients who had health insurance X 72.3 months (95% CI: 55.3-89.3), p=0.03. After adjusting for confounding factors, the lack of health insurance was the only variable independently associated with a lower survival of the b-DMARD (HR 2.54, 95% CI: 1.18 to 5.75). The global LUNDEX was 52.7% at 6 months and 46.9% at 12 months. Conclusions: The average survival of the 1st b-DMARD was 5.5 years. The lack of health insurance was the only variable that negatively influenced the survival of the treatment with the 1st b-DMARD in patients with axSpA.

Radiotherapy plus temozolomide or PCV in patients with anaplastic oligodendroglioma 1p19q codeleted. / Radioterapia mas temozolomida o PCV en pacientes con oligodendroglioma anaplasico con codelecion 1p19q.

INTRODUCTION: Radiotherapy with procarbazine, lomustine, and vincristine (PCV) improves overall survival in patients with anaplastic oligodendroglioma 1p19q codeleted. PATIENTS AND METHODS: This retrospective analysis investigated outcomes in patients with anaplastic oligodendroglioma 1p19q codeleted compared two different protocols (radiotherapy plus temozolomide or PCV). The primary end points were overall survival and progression-free survival. Secondary endpoint was the radiological response. RESULTS: A total of 48 patients were included. Mean age was 43 years (range: 19-66 years), 26 were male (54.1%). Twenty-one patients received PCV and 27 temozolomide. The baseline characteristics were not difference between the groups. The progression-free survival and overall survival in the PCV group were 7.2 and 10.6 years respectively and temozolomide were 6.1 and 9.2 years, both statistically significant. The radiological response was present in 80.9% in PCV arm and 70.2% in temozolomide arm there was not statistical differences. The multivariate Cox model showed only the significant parameters the use of PCV protocol. The toxicity grade 3 or 4 was present in 42.8% in PCV arm and 11.1% in temozolomide arm. CONCLUSIONS: The most common strategy in the Latin America community is the substitution of the PCV for temozolomide. This retrospective study showed superior efficacy of PCV than temozolomide. The Latin American community effort must be made to be able to have the drugs to available for using as a first line of treatment.

TITLE: Radioterapia mas temozolomida o PCV en pacientes con oligodendroglioma anaplasico con codelecion 1p19q.Introduccion. La radioterapia con procarbacina, lomustina y vincristina (PCV) mejora la supervivencia global en pacientes con oligodendroglioma anaplasico con codelecion 1p19q, pero no esta disponible en America Latina. Pacientes y metodos. Analisis retrospectivo comparando dos protocolos diferentes, radioterapia mas temozolomida o PCV, en pacientes con oligodendroglioma anaplasico con codelecion 1p19q. Los objetivos primarios fueron la supervivencia global y la supervivencia libre de progresion, y el objetivo secundario, la respuesta radiologica. Resultados. Se incluyo a 48 pacientes, 26 de ellos varones (54,1%), con una edad media de 43 años (rango: 19-66 años). Veintiun pacientes recibieron PCV, y 27, temozolomida. Las caracteristicas iniciales no tuvieron diferencias entre los grupos. La supervivencia libre de progresion y la supervivencia global en el grupo con PCV fueron de 7,2 y 10,6 años, y en el grupo de temozolomida, de 6,1 y 9,2 años, respectivamente, unos resultados estadisticamente significativos. Hubo respuesta radiologica en el 80,9% en el brazo de PCV y el 70,2% en el brazo de temozolomida. El analisis multivariado de Cox mostro como unico parametro significativo el uso del protocolo PCV. El grado de toxicidad 3-4 estuvo presente en el 42,8% en el brazo de PCV y en el 11,1% en el brazo de temozolomida. Conclusiones. La estrategia mas comun en America Latina es la sustitucion de PCV por temozolomida. Este estudio retrospectivo mostro una eficacia superior de PCV que de la temozolomida. La diferencia obliga a la comunidad latinoamericana a hacer un esfuerzo colectivo para poder tener acceso a los medicamentos para su uso como primera linea de tratamiento.

Desempenho técnico-tático no basquetebol feminino: associação com as posições específicas das atletas / Technical-tactical performance in feminine basketball: association with the athletes' specific positions

O objetivo deste estudo empírico, descritivo e associativo foi analisar a associação entre o nível de desempenho técnico-tático de atletas de categorias de base de basquetebol feminino e suas posições específicas. As participantes foram 49 atletas de equipes de base pertencentes a um clube de basquetebol catarinense, envolvido em diferentes categorias do campeonato estadual de Santa Catarina/Brasil. Realizou-se a coleta de dados por meio de observação estruturada do desempenho técnico-tático das atletas, resultando na análise de 27.420 ações de jogo. Os dados foram transcritos em fichas sistemáticas de registro, com base no Instrumento de Avaliação do Desempenho Técnico-Tático Individual no Basquetebol (IAD-BB), e analisados a partir das componentes adaptação, tomada de decisão e eficácia. O tratamento estatístico envolveu a utilização de recursos descritivos (frequência simples e percentual) e inferenciais (teste Qui-quadrado) no programa SPSS 23, adotando-se o nível de 5% de significância para a interpretação dos resultados. A avaliação geral e por categorias competitivas evidenciaram que as atletas, independentemente da posição, apresentaram os percentuais mais elevados de desempenho adequado na componente eficácia e os mais baixos na adaptação. Evidenciou-se, ainda, que as armadoras apresentaram desempenhos superiores nas três componentes, enquanto o desempenho das pivôs chamou a atenção pelos percentuais mais elevados de desempenho inadequado na componente eficácia, em comparação às alas e às armadoras. Para o avanço da área de análise de jogo no basquetebol, recomenda-se a realização de estudos que investiguem a relação entre os fundamentos de jogo e as posições específicas em que os atletas atuam, assim como outros fatores que podem estar associados à eficácia, além da tomada de decisão e da adaptação...(AU)

The purpose of this empirical, descriptive and associative study was to analyze the association between the level of technical-tactical performance of youth female basketball athletes and their specific positions. Participants were 49 athletes of youth basketball teams belonging to a basketball club from Santa Catarina state/Brazil enrolled in u-13, u-14, u-16 and u-18 categories of the Santa Catarina state championship. Data were collected through a structured observation of the athletes' technical-tactical performance, resulting in 27,420 game actions. Data were transcribed in systematic record sheets, based on the Instrument for Assessment of Individual Technical-Tactical Performance in Basketball (IAD-BB), and analyzed from the components adaptation, decision making, and efficacy. Statistical treatment involved the use of descriptive (simple frequency and percentage) and inferential (Chi-square test) resources in the SPSS 23 program, adopting the level of significance of 5% for results interpretation. General and specific evaluation by competitive categories showed that, regardless of their position, athletes presented the highest percentages of adequate performance in efficacy, and the lowest in adaptation. It was also evidenced that the point guards presented superior performances in the three components, while the centers' performance caught attention by the higher percentages of efficacy's inadequate performance, in comparison to the point guards and small forwards. In order to advance the field of game analysis in basketball, it is recommended to carry out studies that investigate the relationship between the basketball technical-tactical skills and the specific positions in which athletes play, as well as other factors that may be associated with efficacy, besides decision-making and adaptation...(AU)

Interactions of tetracyclines with ovalbumin, the main allergen protein from egg white: Spectroscopic and electrophoretic studies.

The interactions of tetracycline (TC), oxytetracycline (OTC) and chlortetracycline (CTC) with ovalbumin (OVA), the main allergen protein of egg white, were investigated by molecular spectroscopy and electrophoresis at three pH conditions (1.5, 4.6 and 7.4). Molecular and synchronous fluorescence, UV-vis spectroscopy, electrophoresis and 1H NMR were used to study the interaction process. Tetracyclines interact with ovalbumin fluorescence by a static quenching mechanism with non-fluorescent complex formation changing the native protein structure. The binding constant (Kb) ranged from 2.11×104 to 58.4×104Lmol-1, and corresponding thermodynamic parameters were measured at different temperatures and pH values. The binding process was spontaneous (ΔG<0), and the magnitude of the interaction increased in the following order: TC

Risk factors associated with gastroesophageal reflux disease relapse in primary care patients successfully treated with a proton pump inhibitor. / Factores de riesgo asociados a recaída de enfermedad por reflujo gastroesofágico en pacientes de primer nivel de atención exitosamente tratados con inhibidor de la bomba de protones.

BACKGROUND: There are no studies on the factors associated with gastroesophageal reflux disease (GERD) relapse in primary care patients. AIM: To identify the risk factors associated with GERD relapse in primary care patients that responded adequately to short-term treatment with a proton pump inhibitor. PATIENTS AND METHODS: A cohort study was conducted that included GERD incident cases. The patients received treatment with omeprazole for 4 weeks. The ReQuest questionnaire and a risk factor questionnaire were applied. The therapeutic success rate and relapse rate were determined at 4 and 12 weeks after treatment suspension. A logistic regression analysis of the possible risk factors for GERD relapse was carried out. RESULTS: Of the 83 patient total, 74 (89.16%) responded to treatment. Symptoms recurred in 36 patients (48.64%) at 4 weeks and in 13 patients (17.57%) at 12 weeks, with an overall relapse rate of 66.21%. The OR multivariate analysis (95% CI) showed the increases in the possibility of GERD relapse for the following factors at 12 weeks after treatment suspension: basic educational level or lower, 24.95 (1.92-323.79); overweight, 1.76 (0.22-13.64); obesity, 0.25 (0.01-3.46); smoking, 0.51 (0.06-3.88); and the consumption of 4-12 cups of coffee per month, 1.00 (0.12-7.84); citrus fruits, 14.76 (1.90-114.57); NSAIDs, 27.77 (1.12-686.11); chocolate, 0.86 (0.18-4.06); ASA 1.63 (0.12-21.63); carbonated beverages, 4.24 (0.32-55.05); spicy food 7-16 times/month, 1.39 (0.17-11.17); and spicy food ≥ 20 times/month, 4.06 (0.47-34.59). CONCLUSIONS: The relapse rate after short-term treatment with omeprazole was high. The consumption of citrus fruits and NSAIDs increased the possibility of GERD relapse.

Elementos do microssistema esportivo: estudo em contexto de desenvolvimento de atletas de basquetebol / Sporting microsystem elements: study in the context of the development of female basketball athletes

Este estudo foi delineado a partir da Teoria Ecológica do Desenvolvimento Humano e buscou identificar os elementos do microssistema que contribuem para o processo de desenvolvimento de atletas de basquetebol. Participaram da investigação 31 atletas do sexo feminino e dois treinadores vinculados às categorias de formação de um Clube de Basquete do estado de Santa Catarina. A coleta das informações foi realizada por meio de entrevistas semiestruturadas, as quais foram observadas a partir da técnica de análise de conteúdo do tipo categorial. Os resultados revelaram que as atividades molares vivenciadas pelas atletas de basquetebol correspondem tanto ao treinamento físico quanto ao treinamento técnico-tático, possuindo ambos persistência temporal e significado para treinadores e atletas. As relações interpessoais são vistas como sendo de fundamental importância para o sucesso do contexto no desenvolvimento das atletas e em competições de categorias de base; evidenciou-se que especialmente as díades observacionais e de atividade conjunta (reciprocidade e afetividade positiva) se fazem presentes, influenciando nesse processo. Além disso, enfatizou-se a presença de papéis sociais importantes destinados às atletas (em formação, de rendimento, profissionais) e aos treinadores (exigentes, professores, familiares), dependendo da categoria em que estas se encontram. Tais evidências permitem concluir que o conjunto dos elementos presentes no microssistema esportivo estudado tem possibilitado o alcance de sucesso deste contexto no desenvolvimento de atletas do basquetebol feminino no que tange à realidade desta modalidade esportiva em Santa Catarina...(AU)

This study was outlined by the Ecological Theory of Human Development and aimed to identify sporting microsystem elements that contribute to the process of development of female basketball athletes. Participated in the research 31 female athletes and two coaches linked to base categories of a basketball club in the state of Santa Catarina. The information was collected throught semi-structured interviews and was observed using categoric content analysis technique. The results revealed that molar activities experienced by basketball athletes are linked to physical training and technical tactic training, possessing both temporal persistence and meaning for coaches and athletes. Interpersonal relationships are seen critical to achieve success in the context of athlete development and in base category competitions; it was evidenced that especially the observational dyad and joint activity dyad (reciprocity, positive affection) are present, influencing this process. In addition, they emphasized the presence of important social roles for athletes (in formation, performance, professionals) and coahes (demanding coaches, teachers, family members), depending on the category that atlhetes act. These evidences allow to conclude that the elements present in the sporting microsystem studied has made it possible for the achievement of success in this context of development of female basketball players regarding the reality of this sporting modality in Santa Catarina state...(AU

Validation of an Argentine version of Lupus Quality of Life questionnaire.

OBJECTIVE: To determine reproducibility and validity of an Argentine version of the Lupus Quality of Life questionnaire (LupusQoL) and to determine cut-off values in the questionnaire. MATERIALS AND METHODS: One hundred and forty-seven systemic lupus erythematosus patients (American College of Rheumatology 1982/1997) were assessed from April 2014 to July 2014. Demographic and socioeconomic variables were collected, as well as SELENA/SLEDAI, Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index Score, comorbidities and treatment data. Patients completed LupusQoL-Argentine version and European Quality of Life Questionnaire (EuroQoL-5D). Internal consistency and reliability were examined. Convergent validity with EuroQoL-5D was assessed through analysis of latent classes, which established homogeneous categories from the responses of each domain of LupusQoL and for the total. RESULTS: Out of 147 patients, 93.2% were female, mean age 36.4 ± 11.1 years, mean disease duration 2.7 ± 9 years, mean SELENA/SLEDAI 2.7 ± 3 points. The cut-off point that defined good or bad quality of life was 0.739 for EuroQoL 5D and 63 for LupusQoL. Cut-off values for each LupusQoL domain were also defined, creating two classes in each of them. There was moderate to high concordance to classify quality of life (Kappa = 0.74, 95% confidence interval = 0.54, 0.95). CONCLUSION: The Argentine version of LupusQoL is a valid, reliable and reproducible instrument to assess quality of life. In this study, cut-off points that allow the classification of patients regarding whether they have good or bad quality of life are established for the first time.